In 2004, Trump endorsed Eminem in a mock presidential national convention to promote satellite radio station Shade 45. Miller later appeared on The Nightly Show with Larry Wilmore to denounce Trump for his racial views during his run for president in 2016. By 2015, Trump changed his attitude toward Miller again when he ended an interview with The Hill by praising Miller's song as it approached 100 million hits. In early 2013, Trump taunted and threatened legal action against the rapper via a series of exchanges on Twitter. Īs the song garnered more plays, Trump took a more aggressive tone and demanded royalties for using his name, thereby starting a feud with Miller. But the "Donald Trump" song just hit over 20 million, that's not so bad. Probably, it's not the cleanest language you've ever heard. Now, it's named "Donald Trump." Maybe you should pay me a lot of money, but it just did over 20 million people, tuning into Mac Miller. When Mac Miller's 2011 song " Donald Trump" became a Billboard hit, Trump released a YouTube video congratulating the rapper:Ī lot of people are calling me about the Mac Miller rap song. Other major Trump name-checkers include Migos (six songs between 20), Young Thug (six songs between 20), Lil Wayne (five songs between 20) and Raekwon (five songs between 19). Pre-presidency, Rick Ross had the most Trump mentions (nine songs between 20) with Nas running second (seven songs between 19). Many artists have name-checked Trump in more than one song. Because of hip hop's close association with minority communities and its reinvigorated politicization with the Black Lives Matter movement, lyrical depictions of Trump rapidly grew to be more disparaging throughout his campaign and subsequent election as President of the United States. The 2010s marked a left-leaning political shift in musicians' attitude toward Trump as his presence in the public eye changed from that of a business tycoon to a politician, particularly one known for making controversial statements. ĮSPN's political site FiveThirtyEight documented that between 19, 19% of song lyrics about Trump were negative while 60% were positive. Among the earliest of these was The Coup from Oakland, California, who critiqued and mocked Trump on their first two albums released in the early 1990s. While many rappers early to this trend praised Trump's wealth, often as a means to compare their own financial aspirations or success to that of the billionaire businessman, others used their music as a platform to criticize Trump's practices and politics. Among the earliest mentions of Trump in rap lyrics was the Beastie Boys' track "Johnny Ryall" on the 1989 Paul's Boutique album, in which they contrast Donald Trump with his homeless alter-ego, Donald Tramp. Trump's name first appeared in hip hop lyrics during the 1980s when the business mogul became an icon of the ultra rich.
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Play 13 challenging scenarios or make your own with the SimCity Scenario Creator. Inflict 9 disasters-including toxic clouds, plague of locusts, space junk, and a whirlpool. Select hundreds of buildings from SimCity 3000 and all-new Asian and European buildings.Ĭreate unique masterpieces for your metropolis with the Building Architect Plus tool. Protect your citizens from four new disasters. Spruce up your city with over 95 world landmarks. Reunify East and West Berlin in one of 13 scenarios. Re-create cities from around the globe with hundreds of new buildings. Unleash four new disasters including an unforgiving whirlpool and plummeting space junk. Take on 13 challenging scenarios or create your own. Expand your SimCities with two new building sets from Asia and Europe. With SimCity 3000 Unlimited, you get all the great features of the original SimCity 3000 plus much more. Included goodies: manual (English + French + German)+ 2 wallpapers+ quick reference cardĬreate and control your urban empire with more power than ever before. Languages: Text only: Deutsch, English, français, italiano, nederlands, svenskaĬompany: Maxis Software Inc. If you receive an information that your key code has been deactivated by the developer of the game, please contact us immediately and let us know of what happened with your key.ģ.Genre: Simulation - Building - Managerial Make sure to check your library for DLCs or start the game to see if the code didn’t work already for you. If the key you are trying to activate is for a DLC, it could be listed separately from the main game in your library. If you tried to enter your key multiple times, it may be that you activated it already but didn’t see the game in your library yet Log out of your account and log back in, then check your library again. If the error message suggests that your key code has been used already: Instructions to patch the game: 1: Make sure python 2. SimCity 3000 Unlimited was re-released digitally on GOG.com on July 14, 2016. Some of the products sold on have regional restrictions and can be activated only in certain regions or countries. Python 3 script tested under Windows 10 64 bit using Simcity 3000 Unlimited GOG Edition for our testing purposes Python 2.7 script tested under Windows 10 64 bit using Simcity 3000 Unlimited GOG Edition for our testing purposes. SimCity 3000 is a city building simulation video game released in 1999. It also works fine on Windows 10 圆4. I believe it did have a cd check though, as some of the content stayed on the cd, and wasnt copied over during installation. If you see an error message suggesting that your key code can’t be activated in your region, please make sure to check first if you purchased your key for the correct region (by checking the product page on ). The original release of SimCity 3000 (before Unlimited/UK Edition) didnt have any disc related DRM like Safedisc or Securom, but Unlimited did have Safedisc. If you see an error message indicating that your key may be invalid, please check for the following:Īre you activating the product on the proper platform?
Importantly, the abundance of T cell subsets, especially tumor-infiltrating T cells, can influence clinical outcomes and prognosis ( 9). There are two major classes of T cells, namely, CD4+ T cells and CD8+ T cells, each of which includes many functional subpopulations. T cells play a pivotal role in the initiation, progression and treatment of cancer (especially immunotherapy) ( 8). Tumor-infiltrating immune cells are the main immune signature and are strongly associated with the clinical outcome of immunotherapy ( 7). The immune system consists of various proteins, immune cells and tissues with a complex structure and is an important means of host defense ( 6). The current success of antagonists targeting immune checkpoints in a variety of solid tumors ( 3, 4) has rekindled interest in immunotherapy-based therapies for the treatment and prevention of breast cancer ( 4, 5). Likewise, the immune system plays a key role in determining the occurrence of breast cancer and death, the response to standard therapy and the long-term survival of breast cancer patients ( 2). In recent years, increasing research has supported the important role of the immune system in tumorigenesis and cancer development. These sobering data indicate an urgent need for innovative approaches to breast cancer treatment based on chemotherapy and hormonal therapy to reduce disease recurrence and death from this disease. Advances in early detection and treatment have greatly reduced breast cancer mortality, but patients still succumb to the development of metastasis from breast cancer. It is the leading cause of cancer-related deaths among females worldwide ( 1). Our study might contribute to the optimization of the risk stratification for survival and the personalized management of breast cancer.īreast cancer remains a major threat to women’s health and wellness. In addition, a new nomogram was constructed based on the gene signature and clinicopathological features to improve the risk stratification and quantify the risk assessment of individual patients. Our research found that a higher immune infiltration-related risk score (IRS) indicates that the patient has a worse prognosis and is not very sensitive to immunotherapy. Different bioinformatics and statistical approaches were combined to construct a robust immune infiltration-related gene signature for predicting patient prognosis and responses to immunotherapy and chemotherapy. We evaluated the relationship between various immune cells and breast cancer and confirmed the association between immune infiltration and breast cancer progression. Current assessment models are insufficient to accurately predict patient prognosis, and models for predicting treatment response are lacking. 2Department of Breast Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaīreast cancer patients show significant heterogeneity in overall survival.1Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.Yang Peng 1†, Haochen Yu 1†, Yudi Jin 1, Fanli Qu 2, Haoyu Ren 1, Zhenrong Tang 1, Yingzi Zhang 1, Chi Qu 1, Beige Zong 1 and Shengchun Liu 1* If you want to try out some other tricks, check out some of our extra The Sims 4 cheat content. It is important to note though that some of the careers listed above exist only in expansion packs such as The Sims 4: City Living or The Sims 4: Eco Lifestyle so they won’t work unless you have purchased and installed the expansion packs. This pay range is helpful as a comparison tool, and may direct you toward creating your.
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